diff --git a/packages/cryptography/CHANGELOG.md b/packages/cryptography/CHANGELOG.md
index fc57355dea3..3b359b7841a 100644
--- a/packages/cryptography/CHANGELOG.md
+++ b/packages/cryptography/CHANGELOG.md
@@ -11,6 +11,10 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 
 - Add support for Node.js 26 ([#10981](https://github.com/MetaMask/core/pull/10981))
 
+### Fixed
+
+- Derive HKDF from HMAC when the input keying material is empty, as some WebCrypto implementations such as `react-native-quick-crypto` reject an empty HKDF key ([#11024](https://github.com/MetaMask/core/pull/11024))
+
 ## [1.1.2]
 
 ### Fixed
diff --git a/packages/cryptography/src/hkdf.test.ts b/packages/cryptography/src/hkdf.test.ts
index 20ea0eb5838..857c99d23b2 100644
--- a/packages/cryptography/src/hkdf.test.ts
+++ b/packages/cryptography/src/hkdf.test.ts
@@ -208,3 +208,101 @@ describe('hkdfSha512', () => {
     );
   });
 });
+
+describe('HKDF with an empty IKM', () => {
+  const emptyIkm = new Uint8Array(0);
+  const emptyInfo = new Uint8Array(0);
+  const options = { unsafeInputKeyingMaterial: true };
+
+  afterEach(() => {
+    jest.restoreAllMocks();
+  });
+
+  it('does not import the empty IKM as a WebCrypto HKDF key', async () => {
+    // react-native-quick-crypto rejects an empty HKDF key.
+    const importKey = jest.spyOn(globalThis.crypto.subtle, 'importKey');
+
+    const key = await hkdfSha256(
+      emptyIkm,
+      new Uint8Array(32).fill(1),
+      emptyInfo,
+      64,
+      options,
+    );
+
+    expect(bytesToHex(key)).toBe(
+      '0xb5a5789af1d00c74773ef327dc63f0f11c7041252d4916c43a252b92e3358ad272d7e204fba7b0ac19964ebcba5e88e3609cb8c3cafa4b940945df49da83680f',
+    );
+    expect(importKey).not.toHaveBeenCalledWith(
+      'raw',
+      expect.anything(),
+      { name: 'HKDF' },
+      expect.anything(),
+      expect.anything(),
+    );
+  });
+
+  it('uses a zero salt of hash length when the salt is empty', async () => {
+    const key = await hkdfSha256(
+      emptyIkm,
+      new Uint8Array(0),
+      emptyInfo,
+      32,
+      options,
+    );
+
+    expect(bytesToHex(key)).toBe(
+      '0xeb70f01dede9afafa449eee1b1286504e1f62388b3f7dd4f956697b0e828fe18',
+    );
+  });
+
+  it('includes info and derives more than one block', async () => {
+    const key = await hkdfSha256(
+      emptyIkm,
+      new Uint8Array(32).fill(1),
+      info,
+      80,
+      options,
+    );
+
+    expect(bytesToHex(key)).toBe(
+      '0x12f2e1ee5e6ed702856aba724415af4fea6343248bfe221db0dce4ef4f5c2cc7c20a0acdcc06638d2ae58b55240230541813e6acca9936141786fa0bf8b658ca7585a3793a37bfedb9779e1f007f117b',
+    );
+  });
+
+  it('derives key material with HKDF-SHA-384', async () => {
+    const key = await hkdfSha384(
+      emptyIkm,
+      new Uint8Array(48).fill(2),
+      emptyInfo,
+      48,
+      options,
+    );
+
+    expect(bytesToHex(key)).toBe(
+      '0xa64c6c8eba82ddf729d3fcc16b9ef6057a82b4eb594b7c7def352047bcd5135c1d72ad30840f31488454b4b56383ee6a',
+    );
+  });
+
+  it('derives key material with HKDF-SHA-512', async () => {
+    const key = await hkdfSha512(
+      emptyIkm,
+      new Uint8Array(64).fill(3),
+      emptyInfo,
+      100,
+      options,
+    );
+
+    expect(bytesToHex(key)).toBe(
+      '0xeb78d46b71b65b758e187684283d5c1ee6f7c2cfe8149025a74ce46ff3410dfb3364c250215fa6ad98177b5d24e797375bb3426711e00030660c974227774d11e7f85e493893f0666e7feaad813f54206e7407502cdd1f639076c7d30abba283fe45b7de',
+    );
+  });
+
+  it('throws if the key length is longer than HKDF allows', async () => {
+    await expect(
+      hkdfSha256(emptyIkm, salt, emptyInfo, 255 * 32 + 1, options),
+    ).rejects.toThrow(
+      'Invalid key length: HKDF-SHA-256 can derive at most 8160 bytes.',
+    );
+  });
+});
diff --git a/packages/cryptography/src/hkdf.ts b/packages/cryptography/src/hkdf.ts
index 02999f7a6e5..0e290ae2331 100644
--- a/packages/cryptography/src/hkdf.ts
+++ b/packages/cryptography/src/hkdf.ts
@@ -1,7 +1,14 @@
 import type { HashFunction } from './types.js';
+import { toUint8Array } from './utils.js';
 
 const MIN_IKM_LENGTH = 32;
 
+const HASH_LENGTH: Record<HashFunction, number> = {
+  'SHA-256': 32,
+  'SHA-384': 48,
+  'SHA-512': 64,
+};
+
 export type HkdfOptions = {
   /**
    * Skip the minimum IKM length check. Using IKM shorter than 32 bytes
@@ -101,6 +108,12 @@ async function hkdf(
     );
   }
 
+  // Some WebCrypto implementations, such as react-native-quick-crypto, reject
+  // an empty HKDF key, so derive it from HMAC as RFC 5869 defines it.
+  if (ikm.byteLength === 0) {
+    return hkdfFromHmac(ikm, hash, salt, info, keyLength);
+  }
+
   const subtleKey = await globalThis.crypto.subtle.importKey(
     'raw',
     ikm,
@@ -122,3 +135,78 @@ async function hkdf(
 
   return new Uint8Array(derivedBits);
 }
+
+/**
+ * Compute the HMAC of the given data with WebCrypto.
+ *
+ * @param key - The HMAC key.
+ * @param hash - The hash function to use.
+ * @param data - The data to authenticate.
+ * @returns The HMAC.
+ */
+async function hmacSign(
+  key: BufferSource,
+  hash: HashFunction,
+  data: BufferSource,
+): Promise<Uint8Array<ArrayBuffer>> {
+  const subtleKey = await globalThis.crypto.subtle.importKey(
+    'raw',
+    key,
+    { name: 'HMAC', hash },
+    false,
+    ['sign'],
+  );
+
+  return new Uint8Array(
+    await globalThis.crypto.subtle.sign('HMAC', subtleKey, data),
+  );
+}
+
+/**
+ * Derive key material using HKDF built from HMAC, following the Extract and
+ * Expand steps of RFC 5869.
+ *
+ * @param ikm - The input keying material.
+ * @param hash - The hash function to use.
+ * @param salt - The salt to use.
+ * @param info - Context and application-specific information.
+ * @param keyLength - The desired key length in bytes.
+ * @returns The derived key material.
+ */
+async function hkdfFromHmac(
+  ikm: BufferSource,
+  hash: HashFunction,
+  salt: BufferSource,
+  info: BufferSource,
+  keyLength: number,
+): Promise<Uint8Array<ArrayBuffer>> {
+  const hashLength = HASH_LENGTH[hash];
+  const blockCount = Math.ceil(keyLength / hashLength);
+  if (blockCount > 255) {
+    throw new Error(
+      `Invalid key length: HKDF-${hash} can derive at most ${255 * hashLength} bytes.`,
+    );
+  }
+
+  // https://datatracker.ietf.org/doc/html/rfc5869#section-2.2
+  const pseudoRandomKey = await hmacSign(
+    salt.byteLength === 0 ? new Uint8Array(hashLength) : salt,
+    hash,
+    ikm,
+  );
+
+  // https://datatracker.ietf.org/doc/html/rfc5869#section-2.3
+  const infoBytes = toUint8Array(info);
+  const output = new Uint8Array(blockCount * hashLength);
+  let previous = new Uint8Array(0);
+  for (let index = 0; index < blockCount; index++) {
+    const input = new Uint8Array(previous.length + infoBytes.length + 1);
+    input.set(previous);
+    input.set(infoBytes, previous.length);
+    input[input.length - 1] = index + 1;
+    previous = await hmacSign(pseudoRandomKey, hash, input);
+    output.set(previous, index * hashLength);
+  }
+
+  return output.slice(0, keyLength);
+}